Thus, in male liver, 76% of male-specific genes were up regulated and 47% of female-specific genes were down regulated from 3 to 8 wk of age, whereas in female liver 67% of sex-specific genes showed no significant change in expression.
In both sexes, genes up regulated from 3 to 8 wk were significantly enriched ( Overall, the observed changes in gene expression during postnatal liver development reflect the deceleration of liver growth and the induction of specialized liver functions, with widespread changes in sex-specific gene expression primarily occurring in male liver.
Matt Harvey, who once represented the bright future of the franchise, provided the latest drama.
He was ordered by the Mets front office to go home, suspended for three days without pay for violating team rules.
Here, we analyzed 45 mouse liver RNA sequencing (RNA-Seq) data sets collected under diverse conditions to systematically characterize 4,961 liver linc RNAs, 59% of them novel, with regard to gene structures, species conservation, chromatin accessibility, transcription factor binding, and epigenetic states.
Notably, sex-independent genes involved in cell cycle, chromosome condensation, and DNA replication were down regulated from 3 wk to 8 wk, while genes associated with metal ion binding, ion transport and kinase activity were up regulated.
A majority of genes showing sex differential expression in adult liver did not display sex differences prior to puberty, at which time extensive changes in sex-specific gene expression were seen, primarily in males.
], especially with regards to sex-biased gene expression.
Over 1,000 genes are known to be differentially expressed between male and female liver and are regulated primarily by pituitary patterns of growth hormone secretion .